Hospital Trusts in South London are paying out £33.5 million in claims annually, according to new figures.
King's College Hospital had £11.6 million claims against them, Guy's and St Thomas's had £8.1 million, St George's £7.7 million, and Lewisham £11 million.
One fifth of claims come from maternity wards, and account for 60 per cent of the pay outs, with larger hospitals which perform complex procedures facing more claims.
A spokesman for King's College Hospital NHS Foundation Trust said: "We are happy to confirm that the amount paid out by the litigation authority for claims relating to King's has fallen over the last three years. It is worth noting that this may be partly due to the way in which payments are phased over a period of time."
Guy's and St Thomas's NHS Foundation Trust is the largest NHS body in South London, with an annual budget of £145 million and had £8 million of claims against them.
A spokeswoman for Guy's and St Thomas's NHS Foundation Trust said: "Our staff work extremely hard to deliver high quality care and to keep claims to an absolute minimum. We are proud, for example, that our busy maternity service is one of just 14 in the whole country to have achieved the highest level of the Clinical Negligence Scheme for Trusts."
All negligence cases are now handled by the NHS litigation Authority (NHSLA) on behalf of individual trusts.
Claims were also made against Primary Care Trusts (PCT) that look after GPs and community health initiatives.
The PCT paid out over £14,000 in 2004-2005 when someone fell down a manhole.