Up to 150 workers at Salford University are facing redundancy.
It will be the sixth round of job cuts in less than 18 months at the learning institution and comes just two weeks after it was announced 180 administrative and technical staff will be let go in the coming months.
Martyn Moss, regional officer for the University and College Union - which was formed in 2006 and represents over 120,000 people - said individuals have been left "demoralised" by the latest announcement.
"Such an ad hoc approach to axing staff and courses is no way to plan for the future," he added.
Mr Moss urged the institute to explore other options to try to avoid making more people redundant, adding that investment is in fact the best way to build up the university.
Those affected work in the environmental studies, art and design, humanities, life sciences and computer studies and languages departments.
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Posted by Francesca Witney